ABSTRACT
@#This study was designed to investigate the therapeutic effect of anti-inflammatory tripeptide KdPT on ophthalmoxerosis. Male BALB/c mice, 8-week old, were treated with 0.2% benzalkonium chloride solution to establish the ophthalmoxerosis model. Four weeks after modeling, the mice were randomly divided into control group, positive group and the low, medium, high dose groups of KdPT. Each group was given normal saline, artificial tears and 1, 10, 100 μg/mL KdPT, respectively. After 3, 5, 7, 10 and 14 days of treatment, the morphology of the eye surface was observed, and the fluorescein sodium staining score was performed. The amount of tear secretion was measured by phenol red cotton thread and the right corneas were taken out for histopathological analysis after 14 days of treatment. Data showed that there was no significant abnormality in general state and the weight of mice in each group at each time point of treatment. After 14 days of treatment, KdPT can promote the secretion of tear, repair the damaged corneal epithelium, and showed a significant therapeutic effect on ophthalmoxerosis in mice. Based on the data, it is possible for KdPT to be developed as a novel drug for ophthalmoxerosis.
ABSTRACT
@#AIM: To observe the effect of corneal bandage lens on ocular surface repair after pterygium excision combined with limbal stem cell transplantation.<p>METHODS: Totally 52 patients with unilateral primary pterygium were selected from January 2016 to January 2018 in the ophthalmology department of our hospital. All 26 cases(26 eyes)underwent pterygium excision combined with limbal stem cell transplantation and who were placed with bandage lens as the experimental group, the other 26 cases(26 eyes)without bandage lens placed as the control group. Ocular surface disease index(OSDI)questionnaires, tear break-up time(BUT), and corneal fluorescein staining(CFS)were recorded before operation and after operation.<p>RESULTS: BUT in the experimental group was longer than that in the control group(<i>P</i><0.05), OSDI and CFS scores were lower than those in the control group(<i>P</i><0.05)at 2wk, 1mo after operation. Compared with the preoperative situation, BUT in the two groups was shorter, OSDI and CFS scores were higher(<i>P</i><0.05). At 1mo after operation there were no significant differences in BUT, OSDI and CFS between the experimental group and those before the operation(<i>P</i>>0.05), but in the corresponding period, BUT in the control group was still shorter, OSDI and CFS scores were still higher than those before the operation(<i>P</i><0.05).<p>CONCLUSION: Surgical excision combined with autologous limbal stem cell transplantation and placing corneal bandage lens is a safe method to promote corneal healing, improve tear film stability and reduce postoperative discomfort in pterygium patients in the early stage after surgery, which is conducive to the repair of the ocular surface and has certain clinical application value.
ABSTRACT
@#AIM: To evaluate the clinical effect of wearing bandage lens after pterygium excision combined with corneal stem cell transplantation. <p>METHODS: This study was a prospective analysis. Totally 110 cases 110 eyes of pterygium excision combined with corneal stem cell transplantation admitted to our hospital from August 2015 to February 2018 were randomly divided into control group and observation group with 55 cases in each group. Patients in observation group wore bandage lens after operation. Visual analogue scale(VAS)was used to evaluated the pain 1, 3d and 1wk after operation. Fluorescein staining(FL)was used to evaluate the corneal epithelial healing and the incidence of complications. <p>RESULTS: The VAS score and corneal epithelial healing score of the observation group were significantly lower than those of the control group at 1, 3d and 1wk after operation(<i>P</i><0.05). There was no difference in the incidence of complications between the two groups(<i>P</i>>0.05). <p>CONCLUSION: It is safe and effective to wear bandage lens after pterygium excision combined with corneal stem cell transplantation. It can relieve pain and promote epithelial healing after pterygium operation.
ABSTRACT
?AlM: To investigate the clinical characteristics and influencing factors of chronic renal failure ( CRF) patients with dry eye, and to provide clinical reference.?METHODS:Sixty-one cases (122 eyes) of patients with CRF ( CRF group ) and 61 cases ( 122 eyes ) of healthy persons ( control group) were carried out on Schirmer ▏test ( S▏t ) , break-up time of tear film ( BUT ) , corneal fluorescein staining ( FL) , test results of two groups were compared and related factors of dry eye in CRF patients were analyzed.?RESULTS: The results of S▏t and BUT in CRF group were lower than that in the control group (P<0. 05). The proportion of tear secretion reduce in CRF group ( S▏t<10mm/5min) was 49. 2% ( 60/122 ), which was higher than that in the control group ( 10. 0%, 12/122 ), the difference was statistically significant ( X2 = 45. 39, P <0. 05). The percentage of instability of tear film in CRF group (BUT≤10s) was 75. 4% (92/122), which was significantly higher than that in the control group (27. 0%, 33/122) (X2=57. 1, P<0. 05). The positive rate of corneal FL was 37. 7% (46/122), which was higher than that of the control group (10. 7%, 13/122), there was a statistically significant difference (X2= 24. 34, P<0. 05).?CONCLUSlON:CRF patients with a decrease in tear film stability and tear secretion are susceptible population to dry eye, clinically should be paid attention to the treatment.
ABSTRACT
Objectives: To determine the prevalence of dry eye based on dry eye symptoms attending the Department of Ophthalmology and Medicine, Tripura Medical College. Materials and Methods: This study was conducted at Tripura Medical College, Hapania, Agartala, from 1st December 2009 to 31st December 2010. Complete history and ocular examinations was recorded on a pre designed proforma in the Department of Ophthalmology. The diagnosis was made from history and objective dry eye test in the following sequence: tear meniscus height, tear break up time test,fluorescein staining, schirmer test, and rose Bengal staining. If 2 or more of the above test were positive, the patient was deemed to be suffering from dry eye. All patients were sent to the Dept. of Medicine for systemic examination and to rule out any systemic diseases. Results: In this study, total number of patients that presented with dry eye symptoms were 762 and among them dry eye was diagnosed in 403 patients. The Prevalence rate was 3.10% and it was highest in the age of more than 70 years of age. Females had higher prevalence (1.94%) than males (1.15%). Conclusion: The prevalence of dry eye is less in Tripura at around 3.10%. This may be due to the geographical and climatic implication with a high degree of humidity reigning in this region.
Subject(s)
Adult , Aged , Coloring Agents/diagnosis , Diagnostic Techniques, Ophthalmological/methods , Dry Eye Syndromes/diagnosis , Dry Eye Syndromes/epidemiology , Dry Eye Syndromes/etiology , Female , Fluorescein/diagnosis , Hospitals , Humans , Male , India , Population , Prevalence , Rose Bengal/diagnosis , Staining and Labeling/methods , Tears/metabolismABSTRACT
PURPOSE: To evaluate the change of corneal sensitivity and tear film stability before and after cataract surgery using a temporal clear corneal incision in diabetic patients. METHODS: This study included 16 eyes of 16 patients in the diabetic group and 20 eyes of 20 patients in the control group. All patients had phacoemulsification with 3 mm temporal clear corneal incision. All patients were examined for the corneal sensitivity, Schirmer test, tear break-up time, fluorescein staining for ocular surface, and ocular irritation symptom. All values were compared before and after surgery (1, 7, 30, 60, and 90 days). RESULTS: Before surgery, the Schirmer test and tear break-up time were lower in the diabetic group than the normal group, but the difference was not statistically significant. The values of the Schirmer test tended to temporarily increase after surgery and then decrease. The tear break-up time decreased more in the diabetic group than the normal group until postoperative day 7 (P<0.05). The fluorescein staining scores and ocular irritation symptoms were increased in both groups at postoperative day 1 (P<0.05). The temporal corneal sensitivity decreased more in the both groups until postoperative day 7. The central corneal sensitivity decreased more in the diabetic group until postoperative day 7, more in the non diabetic group until postoperative day 1 (P<0.05). Corneal sensitivity decreased more in the diabetic group than the normal group at postoperative day 1 (P<0.05). CONCLUSIONS: Clear corneal incision affected corneal sensitivity and tear film stability in the diabetic group more than the normal group after cataract surgery. The diabetic group experienced temporarily altered corneal sensitivity and tear film stability.